CBD and Anxiety in Mice
As studies into cannabis progress, cannabidiol is being realised more and more for its therapeutic potential. Among the impressive properties it has displayed in mice models, CBD showed instances of working against anxious behaviour.
In a 2015 study, three groups of mice were distributed doses of active cannabinoids. One group received CBD, another THC, and the third a combination of the two. The group that received THC displayed a heightened sense of anxiety, whereas the other two groups did not.
What they drew from the study was that CBD, when used in conjunction with THC, was actively able to decrease particular neurons in the central nucleus that are connected with expressions of fear and anxiety. The implication is that CBD has the ability to reduce anxiety that was brought on through THC.
It’s well-established that delta9-tetrahydrocannabinol (THC) is the psychoactive component of cannabis. The second most well-known component of the cannabis plant, known as cannabidiol (CBD), is as no such effect. Instead, CBD is believed to have therapeutic tendencies.
Another study into these effects suggests that CBD on its own can inhibit social anxiety in mice. Administered an hour before interaction, mice that were given CBD spent more time interacting with unfamiliar mice than the mice who hadn’t been treated.
Furthermore, mice have shown reduced predisposition for obsessive-compulsive disorder when administered CBD. The study compared the effects of CBD on mice against mice who had been administered serotonin selective re-uptake inhibitor (SSRI) medications used to treat anxiety and depression.
The study revealed that CBD has the potential to produce similar relaxing effects to that of the SSRIs. The mice who had received CBD had expressed much milder obsession with burying marbles than their counterparts who displayed the compulsion to bury several marbles. This activity was suggested for its parallels to human obsessive-compulsive disorders.
Mice and rats share similar biological, genetic, and behavioral makeups to humans, which is why they’re often studied in relation to human research. It’s through testing on mice that researchers uncovered the endocannabinoid system (ECS). This system, which functions through a system CB1 receptors in mice, participates in the several other functions of the body, namely anxiety- and depressive-like behaviour.
Performing these experiments into the effects of CBD and its similar cannabinoids has been ongoing for decades. Now that the climate is changing for cannabis, scientists are finding more research opportunity to continue uncovering the potential of the leafy green plant. The hope from these findings is that the science can uncover ways in which CBD can be used as a natural approach to treating anxiety.
Here at YourHemp we do not condone the animal testing procedures, but this is the only current evidence available on CBD oil. We hope that more testing can be made on humans, so that we can fully understand its potential benefits.